When you say that your wife's professional business was listed in Quebec, I understand that you probably entered a business address in Quebec.
You need to enter also the "Province and percentage of business earned outside your province of residence" in the Income, expenses page (bottom of the page).
In your wife's situation you will select Quebec 100%.
UFile will then generate a Quebec return which will comprise form TP-25.
The Quebec return will be eligible for NetFile Quebec.
The federal return will need to be filed on paper because of the T2203, Multiple jurisdiction form.