Found the issue (following is meant for uFile support, other users may not have the 2019 exe file available)
2021 install uses MicrosoftEdgeWebView2RuntimeInstallerX86.exe which causes the issue, I did the following and uFile 2021 installed fine:
. extract the 2019 and 2021 exe file to separate folders
. copy the file NDP452-KB2901907-x86-x64-AllOS-ENU.exe from 2019 extracted folder to 2021 extracted folder
. Update the last line in ini file in 2021 extracted folder from Prerequisites=EdgeWebView2 to Prerequisites=Netfx45
Hope uFile will post new exe file for others after this fix.
G.W got a reaction from RobC in 2021 Windows uFile exe fails to install